What is the difference between Isosteres and Bioisosteres?
Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere.
How do you identify Isosteres?
Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. Consider neon, the noble gas at the end of the second row of the periodic table. To the left of it, fluorine has one fewer electron.
What is the difference between Isoelectronic and Isosteres?
The key difference between isoelectronic and isosteres is that isoelectronic chemical species have similar electronic configurations whereas isosteres are chemical species having similar size, the same number of atoms and valence electrons.
What is bioisosterism Slideshare?
In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound.
What is bioisosterism process?
Bioisosterism is a strategy of Medicinal Chemistry for the rational design of new drugs, applied with a lead compound (LC) as a special process of molecular modification [1].
What is Bioisomerism?
Bioisosterism. Bioisosteres – substituents or groups with chemical or physical similarities that produce similar biological properties.
What is synthesis of 2-quinolones?
Synthesis of 2-quinolones. Recent Literature. A Pd-catalyzed C-H bond activation/C-C bond formation/cyclization cascade process enables the synthesis of quinolinone derivatives from simple anilines as the substrates. This method provides access to quinolinone-containing alkaloids and drug molecules.
How to synthesize quinolines from 2-alkenylanilines?
A rapid synthesis of quinolines from 2-alkenylanilines involves an unexpected DMAP-catalyzed cyclization of 2-alkenylanilines with di- tert -butyl dicarbonate providing a series of tert -butyl quinolin-2-yl carbonates with various functional groups in good yields under mild conditions.
What is the structure of 4-hydroxy-2-quinolone?
4-hydroxy-2-quinolone is a heteroaryl hydroxy compound that is 2-quinolone substituted at position 4 by a hydroxy group. It is a quinolone and a heteroaryl hydroxy compound.
How are O-alkynylanilines converted to 4-hydroxyquinolin-2 (1 h)-1 derivatives?
Various o -alkynylanilines can be converted under mild reaction conditions to 4-hydroxyquinolin-2 (1 H )-one derivatives in high yield in the presence of a catalytic amount of a silver salt, carbon dioxide and a base. T. Ishida, S. Kikuchi, T. Yamada, Org. Lett., 2013 , 15, 3710-3713.