Can estradiol be taken sublingually?

Sublingual Tablet – We recommend taking estradiol tablets sublingually, which means to let it dissolve under the tongue rather than swallowing them. This typically takes about 5-10 minutes for the tablet to completely dissolve.

Is sublingual estradiol better?

According to Price et al., sublingual administration results in rapid absorption with significantly higher estradiol levels than does comparable oral dosing. This is likely because sublingual administration will bypass metabolism by the intestines and liver.

What is micronized estradiol?

Micronized 17beta-estradiol (E2) was used as oral replacement therapy in 369 patients with estrogen deficiency and related menopausal symptoms. Over 95 percent of 319 patients evaluable for efficacy gained satisfactory relief of their symptoms from cyclic (on 21 days/off 7 days) E2 therapy.

Can estradiol valerate be taken sublingually?

Sublingual administration of estradiol valerate bypasses the first pass that occurs with the oral route and results in higher levels of estradiol and improved cycle control. Sublingual estradiol valerate is also used in hormone therapy for transgender women.

How long does sublingual estradiol last?

8–18 hours
Pharmacokinetics of estradiol

Clinical data
Elimination half-life Oral: 13–20 hours Sublingual: 8–18 hours Transdermal (gel): 37 hours IM (as EV ): 4–5 days IM (as EC ): 8–10 days IV (as E2 ): 0.5–2 hours
Excretion Urine: 54% Feces: 6%

When should you take estradiol?


  1. Adults—One capsule once a day, in the evening. Each capsule contains 1 milligram (mg) estradiol and 100 mg progesterone.
  2. Children—Use is not recommended.

What time of day should you take estradiol?

Adults—One capsule once a day, in the evening. Each capsule contains 1 milligram (mg) estradiol and 100 mg progesterone. Children—Use is not recommended.

What is the difference between buccal and sublingual absorption?

Sublingual administration involves placing a drug under your tongue to dissolve and absorb into your blood through the tissue there. Buccal administration involves placing a drug between your gums and cheek, where it also dissolves and is absorbed into your blood.

Is it better to take micronized estradiol orally or sublingually?

I have met several transwomen who are taking micronized estradiol by simply swallowing it (oral administration), when there is much more benefit to be had by taking it sublingually (dissolving it under your tongue). Some claim they “heard” that the two were about the same, and it doesn’t matter which method they use.

What are the benefits of sublingual micronized hormone replacement therapy (HRT)?

Sublingual micronized HRT favorably decreases serum and urine markers of bone metabolism, prevents bone loss, and results in a slight increase in spine and hip bone mineral density. Although the addition of testosterone to HRT for 1 year did not result in added benefit to the spine bone mineral dens …

What is the difference between oral and sublingual estradiol tablets?

Oral estradiol tablets can be taken sublingually instead of orally and this allows for greater bioavailability and higher estradiol levels than with oral use. For this reason, sublingual estradiol is frequently used in transfeminine people.

Does micronized estradiol and progesterone affect bone mineral density?

Sublingual administration of micronized estradiol and progesterone, with and without micronized testosterone: effect on biochemical markers of bone metabolism and bone mineral density