Do COX-2 inhibitors affect prostaglandins?
COX-2 inhibitors are a subclass of nonsteroidal antiinflammatory drugs (NSAIDs). NSAIDs work by reducing the production of prostaglandins, chemicals that promote inflammation, pain, and fever.
Which prostaglandins does COX-2 produce?
COX-2 was thought to be induced as the result of inflammation and responsible for producing prostaglandins such as prostaglandin E2.
What is the function of prostaglandin D2?
Effects. PGD2 causes a contraction of the bronchial airways. Its concentration in asthma patients is 10 times higher than in control patients, especially after it is brought into contact with allergens. It is involved in the regulation of reducing body temperature in sleep, and acts opposite to PGE2.
What are some COX-2 inhibitor drugs?
The main brands of COX-2 inhibitor drugs currently on the market are Celebrex and Bextra (since the Vioxx recall). COX-2 inhibitors are a newer type of NSAID that block the COX-2 enzyme at the site of inflammation.
What is a selective COX-2 inhibitor?
The COX-2 selective inhibitors, such as rofecoxib and celecoxib, were introduced to decrease the gastrointestinal morbidity and mortality associated with older non-steroidal anti-inflammatory drugs (NSAIDs) which inhibit both the COX-1 and the COX-2 enzymes.
Is prostaglandin D2 a vasodilator?
Prostaglandin D2 (PGD2) can cause pulmonary vasoconstriction or vasodilation depending on animal species and age.
Where is prostaglandin D2 produced?
Prostaglandin (PG) D2 is the most potent endogenous sleep-promoting substance. PGD2 is produced by lipocalin-type PGD synthase localized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain, and is secreted into the cerebrospinal fluid as a sleep hormone.
Is Motrin a COX-2 inhibitor?
Over-the-counter NSAID medications include aspirin, ibuprofen (Advil, Motrin, and other brand names), and naproxen (Aleve), but selective COX-2 inhibitor NSAIDs are prescription medications that are more specialized in the way they work on inflammation.