How long does HBV treatment last?

Duration of treatment is at least 1 year with lamivudine and adefovir; longer duration of treatment is needed in most patients, but the optimal duration of treatment and the criteria for stopping treatment have not been established.

Can inactive hepatitis B become active?

Patients can remain inactive, or may evolve into chronic active hepatitis or hepatocellular carcinoma.

What is anti-HBs Cmia?

Normal: Nonreactive. Comment. Specimens submitted for detection of antibody to HBV surface antigen (Anti-HBs) are tested using a chemiluminescent microparticle immunoassay (CMIA) that detects IgG anti-HBs. This automated assay on the Abbott Architect system provides a quantitative determination of Anti-HBs.

What is anti-HBs negative?

For hepatitis B surface antibody (anti-HBs), a level less than 5 mIU is considered negative, while a level more than 12 mIU is considered protective. Any value between 5 and 12 mIU is indeterminate and should be repeated.

What are the treatment guidelines for hepatitis B (HBV)?

In the United States, two main groups—the AASLD and Hepatitis B Primary Care Workgroup—have issued hepatitis B treatment guidance. According to these groups, antiviral therapy is indicated in patients with chronic HBV and cirrhosis, regardless of ALT level.

How is the decision to treat HBV made?

The decision to treat HBV is based on several factors including blood tests results, the patient’s age, and the risk of developing cirrhosis or liver cancer. Sometimes a liver biopsy is needed to see if there is significant liver damage (or scarring) to make a decision.

Can HIV prep help people with HBV?

Since both of the medication combinations used for HIV PrEP are highly active against HBV, any person with chronic HBV who is receiving HIV PrEP is also receiving treatment for HBV.

When is pegylated interferon indicated for the treatment of hepatitis B?

Patients with both chronic hepatitis B and hepatitis D infection may need pegylated interferon alone or combined with an oral hepatitis B pill. Pegylated interferon therapy is usually given for 48 weeks.