What is hepatic steatosis and/or fibrosis?
FLD can progress to a condition called steatohepatitis when the accumulation of fat in the liver causes inflammation, cell death, and scarring. Long-standing steatohepatitis leads to liver fibrosis as scar tissue builds up and replaces healthy liver tissue.
What is Perisinusoidal fibrosis?
Liver fibrosis is characterized by the replacement of liver tissue by extracellular matrix components including collagens. Hepatic stellate cells, also termed perisinusoidal cells, are found in the perisinusoidal space of the liver and are the main matrix-producing cells that drive liver fibrosis.
What does it mean if you have hepatic steatosis?
Fatty liver disease means you have extra fat in your liver. You might hear your doctor call it hepatic steatosis. Heavy drinking makes you more likely to get it. Over time, too much alcohol leads to a buildup of fat inside your liver cells.
What is the typical pattern of fibrosis in nonalcoholic steatohepatitis?
Fibrosis in nonalcoholic steatohepatitis. The characteristic pattern of fibrosis in nonalcoholic steatohepatitis is perisinusoidal/pericellular (chicken wire) fibrosis, which usually begins in zone 3 (reticulin staining). Glycogenated nuclei
What is the histology of hepatic steatosis?
The hepatic histology varies from isolated hepatic steatosis alone “first hit” to fatty liver accompanied by hepatocellular damage plus inflammation known as steatohepatitis “second hit” which is followed by the development of fibrosis.
What causes steatosis and fibrosis progression in chronic hepatitis C (HC)?
Fartoux L, Poujol-Robert A, Guechot J, Wendum D, Poupon R, Serfaty L. Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C. Gut. 2005;54:1003–1008. [PMC free article][PubMed] [Google Scholar]
What is the pathophysiology of steatohepatitis?
Objective: Steatohepatitis is a morphological pattern of liver injury that may be seen in alcoholic or nonalcoholic liver disease. This pattern may occur with obesity, diabetes, the use of certain drugs, or the cause may be idiopathic.
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