Is lymphogranuloma venereum the same as Chlamydia?
Lymphogranuloma venereum is an ulcerative sexually transmitted infection of the genital area caused by Chlamydia trachomatis that is transmittable by vaginal, oral or anal sex.
Does Chlamydia cause lymphogranuloma venereum?
Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by a particular strain of chlamydia bacteria. LGV is relatively rare in Scotland and is mostly acquired by men who have sex with men.
How effective is azithromycin with Chlamydia?
Azithromycin works to treat genital chlamydia in both men and women by stopping the bacteria from multiplying. Studies suggest that a one-gram dosage has 97% efficacy. That means that for every 100 people who take azithromycin to treat chlamydia, 97 will be cured and three will not be cured.
How long does lymphogranuloma venereum last?
This lesion heals after a few days and most people are not aware of it. Over the next two to six weeks, the infection spreads to the local lymph glands usually in the groin or inside the pelvis.
How is lymphogranuloma venereum transmitted?
LGV is spread through unprotected anal, oral or vaginal sexual contact, especially if there is trauma to the skin or mucous membranes. It can also be spread via sharing of sex toys between partners.
How is lymphogranuloma venereum diagnosis?
Diagnosis has usually been made by detecting antibodies to chlamydial endotoxin (complement fixation titers > 1:64 or microimmunofluorescence titers > 1:256) or by genotyping using a polymerase chain reaction-based NAAT.
How is Lymphogranuloma venereum (LLV) treated?
Lymphogranuloma venereum causes potentially severe infections with possibly irreversible sequels if adequate treatment is not begun promptly. Early and accurate diagnosis is essential. Doxycycline is the drug of choice. Pregnant and lactating women should be treated with erythromycin or azithromycin.
What is the pathophysiology of lymphogranuloma venereum (LGV)?
Lymphogranuloma venereum primarily affects the lymphatic system. Chlamydia trachomatisserovars extend from the primary infection site to the regional lymph nodes and cause a lymphoproliferative reaction, facilitated by binding of Chlamydia trachomatis to the epithelial cells. Binding occurs via heparin sulfate receptors.
What are the treatment options for leukocytoclastic vasculitis (LGV)?
All exposed partners of LGV probable or confirmed patients in the last 60 days should receive testing and empiric treatment with a chlamydial regimen (doxycycline 100mg PO BID for 7 days or 1gm azithromycin one-time dose).
What are the possible adverse reactions to minocycline for chlamydia?
Fever, lymphadenopathy, eosinophilia, lymphocytosis, hepatitis, and dermatitis: a severe adverse reaction to minocycline. J Am Acad Dermatol. 1997;36(2):347–350. [PubMed] [Google Scholar] 70. Annan NT, Sullivan AK, Nori A, et al. Rectal chlamydia – a reservoir of undiagnosed infection in men who have sex with men. Sex Transm Infect.