Is PKA the same as PKC?

The two most important kinases involved in phosphorylation of ion channel receptors are protein kinase C (PKC) and cAMP-dependent protein kinase A (PKA).

What is PKC and PKA?

The protein kinase A (PKA) and protein kinase C (PKC) signaling pathways appear to interact in regulating phenylethanolamine N-methyltransferase (PNMT) promoter-driven gene transcription in PC12 cells.

What does pKa do in the brain?

In neurons, enhanced PKA signaling elevates synaptic plasticity, promotes neuronal development, and increases dopamine synthesis.

What does PKA do in the brain?

What is PKC responsible for?

Protein kinase C (PKC) family members regulate numerous cellular responses including gene expression, protein secretion, cell proliferation, and the inflammatory response. The basic protein structure includes an N-terminal regulatory region connected to a C-terminal kinase domain by a hinge region.

What do all kinases do?

Kinases are used extensively to transmit signals and regulate complex processes in cells. Phosphorylation of molecules can enhance or inhibit their activity and modulate their ability to interact with other molecules.

Is PKA an effector molecule?

Protein kinase A (PKA) is activated by elevations in cAMP and is a prominent and well-studied effector of cAMP signaling. PKA exists as a heterotetramer of two catalytic and two regulatory subunits.

Do PKA and PKC interact to regulate phenylethanolamine N-methyltransferase promoter-driven gene transcription in PC12 cells?

The protein kinase A (PKA) and protein kinase C (PKC) signaling pathways appear to interact in regulating phenylethanolamine N-methyltransferase (PNMT) promoter-driven gene transcription in PC12 cells.

What is the target region for synergistic stimulation by PKA and PKC?

PNMT promoter analysis further showed that synergistic stimulation by PKA and PKC involves DNA sequences between – 442 and – 392 bp, and potentially a GCM binding element lying within this region. Colforsin / pharmacology Cyclic AMP-Dependent Protein Kinases / metabolism*

How do EGR-1 and Sp1 mediate PKA and PKC regulation?

PKA and PKC regulation seems to be mediated in part by Egr-1 and Sp1 through their consensus elements in the PNMT promoter.